snabelen.no

datum (n=1)hey Covid-Competent, well-informed folks! I have a favour to ask!has anyone bookmarked a good reference for what % of SARS-CoV-2 cases are due to fomite transmission?the US CDC was at one point saying:<blockquote>each contact with a contaminated surface has less than a 1 in 10,000 chance of causing an infection [1]</blockquote>but that's not a % of infections, it's per contact with contaminated surface. That's supported a few ways, eg. by a sampling that included counting touchpoints:<blockquote>The estimated risk of infection from touching a contaminated surface was low (less than 5 in 10,000) by quantitative microbial risk assessment [2]</blockquote>but that study didn't actually culture virus, they checked RNA levels and counted touches (and again, is per contaminated touch, not per case)Try as I might, I can't actually find a grounded estimate of how many actual infections have been fomite-driven at any point in the SARS-CoV-2 pandemic.[1] <a href="https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/more/science-and-research/surface-transmission.html" rel="nofollow noopener" translate="no" target="_blank">https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/more/science-and-research/surface-transmission.html</a> [2] <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7927285/" rel="nofollow noopener" translate="no" target="_blank">https://pmc.ncbi.nlm.nih.gov/articles/PMC7927285/</a><a href="https://groups.zeroes.ca/profile/askazero" class="u-url mention" rel="nofollow noopener" target="_blank">@askazero</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVIDIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVIDIsAirborne</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a>

datum (n=1)MD in the UK:<blockquote>The amount of people I know who now have cognitive issues is staggering. Young, old, it doesnt matter. These are ‘non long Covids’. Biobank called it early- loss of grey matter/reduced volume. People making mistakes everywhere, can’t remember simple lists, can’t find words etc [1]</blockquote>Don't try and say this doesn't ring a bell, if you live in a community of more than 10.[1] Dr. Taylor, <a href="https://bird.makeup/users/drclairetaylor/statuses/1938803665760067960" rel="nofollow noopener" translate="no" target="_blank">https://bird.makeup/users/drclairetaylor/statuses/1938803665760067960</a><a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongCOVID</a>

datum (n=1)Too bad the main body of <a href="https://www.sciencedirect.com/science/article/abs/pii/S0306452225006980" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/abs/pii/S0306452225006980</a> is paywalled. The intro gives a great overview of the current state of knowledge around Long COVID neuropathy:<blockquote>Specifically neuropsychiatric sequelae appear to be often reported by individuals recovering from COVID-19, with about a third of patients presenting fatigue, brain fog and sleep disturbances, and about one fourth anxiety and depression (Premraj et al., 2022); of particular interest, the prevalence of such symptoms appears to increase when investigating long (beyond 6 months) rather than short term consequences of the infection (Premraj et al., 2022).Significant longitudinal effects were identified in a large UK Biobank sample by comparing brain MRI scans acquired before and after SARS-CoV-2 infection. The study reported a substantial reduction in cortical thickness, specifically in the orbitofrontal cortex and the parahippocampal gyrus. Additionally, widespread alterations in white matter microstructure were observed, with decreased integrity in tracts involving the orbitofrontal cortex, anterior cingulate cortex, insular regions, and the amygdala (Douaud et al., 2022).Magnetic resonance imaging studies in patients from 2 to 4 months after infection compared to healthy controls (HC) have shown, independently of illness severity, changes in WM microstructure, especially in the frontal and limbic systems (Qin et al., 2021, Silva et al., 2021), and in functional connectivity, in particular in the visuospatial network (Silva et al., 2021). Similarly, a reduction in fiber density has been reported in association, projection, and commissural tracts (Bispo et al., 2022). Further, recent longitudinal studies showed that WM alterations persist up to 2 years after the infection (Huang et al., 2022, Huang et al., 2023), suggesting that long term consequences of COVID-19 could be associated with long-lasting changes in brain structure.</blockquote>via <a href="https://zeroes.ca/@Brad" class="u-url mention" rel="nofollow noopener" target="_blank">@Brad</a> <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a>

datum (n=1)<a href="https://c.im/@tc_morekindness" class="u-url mention" rel="nofollow noopener" target="_blank">@tc_morekindness</a> <a href="https://zeroes.ca/@broadwaybabyto" class="u-url mention" rel="nofollow noopener" target="_blank">@broadwaybabyto</a> Rapid antigen tests (RATs) have generally had very low sensitivity for years now:"Only 6 out of the 26 COVID-19 RATs yielded faint test lines using buffer spiked with the lowest concentrations" and some RAT brands were essentially unable to show positive to a human eye: <a href="https://www.sciencedirect.com/science/article/pii/S0039914024005265" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/pii/S0039914024005265</a>Omicron sensitivities of appx. 20-60% in nine different brands of RAT: <a href="https://link.springer.com/article/10.1007/s00430-022-00730-z/tables/3" rel="nofollow noopener" translate="no" target="_blank">https://link.springer.com/article/10.1007/s00430-022-00730-z/tables/3</a>Many tests are orders of magnitude - 10x, 100x! - less sensitive for Omicron than for wild type: <a href="https://www.medrxiv.org/content/10.1101/2021.12.18.21268018v1.full.pdf" rel="nofollow noopener" translate="no" target="_blank">https://www.medrxiv.org/content/10.1101/2021.12.18.21268018v1.full.pdf</a><a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/maskUp" class="mention hashtag" rel="nofollow noopener" target="_blank">#maskUp</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/RapidAntigenTests" class="mention hashtag" rel="nofollow noopener" target="_blank">#RapidAntigenTests</a>

datum (n=1)Highlights from <a href="https://mstdn.ca/@ducky" class="u-url mention" rel="nofollow noopener" target="_blank">@ducky</a>'s weekly COVID-19 summaries <a href="https://covidbc.webfoot.com/2025/05/24/2025-05-24-general/" rel="nofollow noopener" translate="no" target="_blank">https://covidbc.webfoot.com/2025/05/24/2025-05-24-general/</a>lineages of interest at the moment:<blockquote>JN.1 -> KP.1.1 -> LP.8 -> LP.8.1 XBB -> GW.5.1; XBB -> FL.13.4; GW.5.1+FL.13.4 -> XDE BA.2 -> BA.2.86 -> JN.1 JN.1+XDE -> XDV.1 -> ? -> XDV.1.5.1 -> ? -> NB.1.8.1</blockquote>2/ 🧵<a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a>

datum (n=1)<a href="https://mstdn.ca/@ducky" class="u-url mention" rel="nofollow noopener" target="_blank">@ducky</a> has kindly again shared summaries from her COVID-19 reading this week! <a href="https://covidbc.webfoot.com/2025/05/24/2025-05-24-general/" rel="nofollow noopener" translate="no" target="_blank">https://covidbc.webfoot.com/2025/05/24/2025-05-24-general/</a>Highlights:<blockquote>the [FDA] anticipates requiring large randomized controlled trials with the controls getting a placebo for all vaccines — even for just updating the strains used in previously approved vaccines. (Yes, giving some participants an ineffective treatment when an effective treatment is known is highly unethical.) </blockquote>This modern globalized life, with high velocity human transportation, requires guardrails not necessary at a plod. Influenza and SARS-CoV-2 simply recombine and mutate too frequently to do studies with 12-month endpoints, and the policy announcement she cites says they will<blockquote>demand robust, gold-standard data on persons at low risk</blockquote>which, if they choose, could be taken to mean longitudinal studies1/ 🧵via <a href="https://mstdn.ca/@ducky/114567116220929081" rel="nofollow noopener" translate="no" target="_blank">https://mstdn.ca/@ducky/114567116220929081</a><a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/publicHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#publicHealth</a> <a href="https://zeroes.ca/tags/vaccines" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccines</a>

datum (n=1)Imagine a faith that puts the well-being of people ahead of corporate interests in 2025.<a href="https://www.stmargaretscedarcottage.ca/why-are-we-still-masking.html" rel="nofollow noopener" translate="no" target="_blank">https://www.stmargaretscedarcottage.ca/why-are-we-still-masking.html</a>THIS is what living a moral life can look like. Caring about others, refusing to perpetuate false narratives, protecting oneself, following evidence as it accumulates.BONUS: THIS WEEK they're selling ultra-quiet air purifiers at a discount, to fundraise <a href="https://www.stmargaretscedarcottage.ca/order-your-air-cleaner.html" rel="nofollow noopener" translate="no" target="_blank">https://www.stmargaretscedarcottage.ca/order-your-air-cleaner.html</a>h/t a zero :mastomask: 👍 <a href="https://zeroes.ca/tags/BC" class="mention hashtag" rel="nofollow noopener" target="_blank">#BC</a> <a href="https://zeroes.ca/tags/Vancouver" class="mention hashtag" rel="nofollow noopener" target="_blank">#Vancouver</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARS2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2</a> <a href="https://zeroes.ca/tags/religion" class="mention hashtag" rel="nofollow noopener" target="_blank">#religion</a> <a href="https://zeroes.ca/tags/faith" class="mention hashtag" rel="nofollow noopener" target="_blank">#faith</a>

datum (n=1)Are you Covid-Competent and wishing for some emotional and rational support as much of the world cosplays 2019?<a href="https://whn.global/stuck-in-the-middle-with-masking-playing-the-long-game-in-a-short-sighted-age/" rel="nofollow noopener" translate="no" target="_blank">https://whn.global/stuck-in-the-middle-with-masking-playing-the-long-game-in-a-short-sighted-age/</a> is trending at <a href="https://zeroes.ca/explore/links" translate="no" rel="nofollow noopener" target="_blank">https://zeroes.ca/explore/links</a> for good reason. Short, accessible, a respected MD who is living according to clear evidence.<a href="https://zeroes.ca/tags/COVIDIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVIDIsNotOver</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/Pandemic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pandemic</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a>

datum (n=1)that Blood Advances paper aligns with earlier autopsy results, and confirmed<blockquote>SARS-CoV-2+ megakaryocytes are present in lung and brain autopsy tissues from deceased donors who had COVID-19</blockquote>But heck! We already knew MKs were long-term impacted. This from 2024 <a href="https://ashpublications.org/bloodadvances/article/8/11/2777/515445/SARS-CoV-2-infection-modifies-the-transcriptome-of" rel="nofollow noopener" translate="no" target="_blank">https://ashpublications.org/bloodadvances/article/8/11/2777/515445/SARS-CoV-2-infection-modifies-the-transcriptome-of</a> - though in mice gives what I guess should be an obvious outcome, since the immune system isn't open-loop:<blockquote>Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow. [...] at peak SARS-CoV-2 viremia, when the disease primarily affected the lungs, MKs were not significantly different from those from healthy mice. Conversely, a significant divergence in the MK transcriptome was observed during systemic inflammation, although SARS-CoV-2 RNA was never detected in the BM, and it was no longer detectable in the lungs. Under these conditions, the MK transcriptional landscape was enriched in pathways associated with histone modifications, MK differentiation, NETosis, and autoimmunityand autoimmunity</blockquote>The breadcrumbs are everywhere.fin/🧵 <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/Covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#immunology</a>

datum (n=1)That aligns with results from 2022-2023 like <a href="https://ashpublications.org/bloodadvances/article/7/15/4200/494910/Circulating-SARS-CoV-2-megakaryocytes-are" rel="nofollow noopener" translate="no" target="_blank">https://ashpublications.org/bloodadvances/article/7/15/4200/494910/Circulating-SARS-CoV-2-megakaryocytes-are</a> which found<blockquote>Using peripheral blood, we show that megakaryocytes are increased in the systemic circulation in COVID-19</blockquote>peripheral blood - circulating!!<blockquote>SARS-CoV-2–containing megakaryocytes are a strong risk factor for mortality and multiorgan injury</blockquote>2/🧵 <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/Covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#immunology</a>

datum (n=1)So. How about this careful result demonstrating viral replication inside megakaryocyte immune cells?<blockquote>transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.</blockquote>Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.That said:<blockquote>bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up</blockquote>short 🧵 <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#immunology</a>

datum (n=1)<a href="https://forall.social/@themaskerscomic" class="u-url mention" rel="nofollow noopener" target="_blank">@themaskerscomic</a> this is really remarkably solid data<blockquote>The cohort included 297,920 SARS-CoV-2-positive individuals and 915,402 SARS-CoV-2-negative controls. Every individual had at least a six-month follow-up after cohort entry</blockquote>With a range of risk ratios from roughly +25% to +200%! That's up to triple the risk!<blockquote>children and adolescents [...] infected with SARS-CoV-2 exhibited increased risks for a range of post-acute cardiovascular outcomes, with RR [risk ratio] between 1.26 and 2.92</blockquote>and things have not gotten better with newer variants:<blockquote>similar cardiovascular outcomes in children infected with the Delta and Omicron variants</blockquote><a href="https://www.nature.com/articles/s41467-025-56284-0" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s41467-025-56284-0</a> also via <a href="https://mstdn.science/@TRyanGregory" class="u-url mention" rel="nofollow noopener" target="_blank">@TRyanGregory</a> <a href="https://zeroes.ca/tags/COVIDIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVIDIsNotOver</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/pediatrics" class="mention hashtag" rel="nofollow noopener" target="_blank">#pediatrics</a> <a href="https://zeroes.ca/tags/cardiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#cardiology</a> <a href="https://zeroes.ca/tags/PASC" class="mention hashtag" rel="nofollow noopener" target="_blank">#PASC</a> <a href="https://zeroes.ca/tags/LC" class="mention hashtag" rel="nofollow noopener" target="_blank">#LC</a> <a href="https://zeroes.ca/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongCOVID</a>

datum (n=1)This preprint seems so good! [edit: pre-proof not pre-print, it has been peer reviewed and the data passed muster, but might have formatting, grammar, and spelling tweaks]<blockquote>goals were: a) to detect viral load in indoor air in different areas and floors of a separate COVID building in a hospital [...], b) to evaluate the effect of an air-cleaner in the reduction of viral load in the presence of patients, and c) to examine the correlation between viral presence in the air and particle matter burden.</blockquote>their methodology is making me happy!Their system separated aerosols into > 2.5 μm, 1.0 to 2.5 μm, 0.5 to 1.0 μm, 0.25 to 0.50 μm, and < 0.25 μm, and found<blockquote>SARS-CoV-2 was detected in all different fractions and the highest viral loads were detected at stages A (> 2.5 μm) and B (1 - 2.5 μm).</blockquote>however this was in open-window conditions, ie. low CO2 and higher airflow; sampling with the same equipment in households, they found <blockquote>the highest amount was detected in Stage 4 (0.25 - 0.5 μm) </blockquote>The data is mostly PCR but they did do some sequencing, and positively confirmed the dominant variants were stable through the study, and not confounding.Note the air cleaner was a "Airocide (APS GCS-25 model) air purifier" which uses "photocatalytic oxidation technology" as well as 254nm UV, with no HEPA or other mechanical filter.Also, this is vindicating for those of us pleading with folks to not immediately de-mask in the hallway:<blockquote>the highest concentration was detected in COVID clinic rooms displaying a high peak of 1123 copies/m3, whereas at the corridor area showed 481 copies/m3</blockquote>Also highly of note, they could not detect any virus in the areas that were upstream of negative-pressure COVID-19 care. So yes, home isolation protocols that emphasize negative pressure zones absolutely are well founded!<a href="https://www.sciencedirect.com/science/article/pii/S0021850225000643" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/pii/S0021850225000643</a> via <a href="https://aus.social/@Sidherian" rel="nofollow noopener" translate="no" target="_blank">https://aus.social/@Sidherian</a><a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVIDIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVIDIsNotOver</a> <a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsAirborne</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/PublicHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#PublicHealth</a> <a href="https://zeroes.ca/tags/CleanAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanAir</a>

datum (n=1)<blockquote>These findings support the “Broken Bridge Syndrome” hypothesis, positing that structural disconnections between the brainstem and cerebellum contribute to PCS [Long COVID] symptomatology. Furthermore, we propose that chronic activation of the Extended Autonomic System (EAS), encompassing the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system, may perpetuate these symptoms</blockquote>In this high quality brain volume data,<blockquote>Significant volume loss was observed in the superior cerebellar peduncle (SCP) in LC patients compared to healthy controls (LC: 219.74 mm³ vs. controls: 347.03 mm³, p < .001, Hedges’ g = 3.31). Furthermore, reduced volumes were evident in the dorsal raphe (DR) and midbrain reticular formation (mRt) (p < .001)</blockquote>It was not metabolism-marker scanning, but volumentric, so they were able to capture:<blockquote>Three-dimensional reconstructions revealed deformities in the 4th ventricle and cerebellar peduncles, suggesting impaired cerebrospinal fluid dynamics [...] Importantly, these volume reductions and FA changes correlated with motor deficits, proprioceptive dysfunction, and autonomic dysregulation</blockquote>TLDR?<blockquote>Our findings reveal significant structural and functional alterations in the brainstem and cerebellar peduncles of LC patients</blockquote><a href="https://www.medrxiv.org/content/10.1101/2025.04.08.25325108v1" rel="nofollow noopener" translate="no" target="_blank">https://www.medrxiv.org/content/10.1101/2025.04.08.25325108v1</a>via <a href="https://zeroes.ca/explore/links" translate="no" rel="nofollow noopener" target="_blank">https://zeroes.ca/explore/links</a><a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVIDIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVIDIsNotOver</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a>

datum (n=1)Some highlights from <a href="https://mstdn.ca/@ducky" class="u-url mention" rel="nofollow noopener" target="_blank">@ducky</a> 's weekly roundup at <a href="https://covidbc.webfoot.com/2025/03/28/2025-03-28-general/" rel="nofollow noopener" translate="no" target="_blank">https://covidbc.webfoot.com/2025/03/28/2025-03-28-general/</a><blockquote>SARS-CoV-2 can interact with / activate the CD147 receptor to get into lymphocytes (T-cells and B-cells). (<a href="https://www.sciencedirect.com/science/article/pii/S2319417023000872" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/pii/S2319417023000872</a>)</blockquote> <blockquote>women are 13.4 times more likely to get Long COVID if they are 🤰pregnant than if they are 🚫🤰not, with the danger highest if they catch COVID-19 in the third trimester. (<a href="https://www.sciencedirect.com/science/article/abs/pii/S0002937825001474" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/abs/pii/S0002937825001474</a>)</blockquote> <blockquote>the rate of cases of postural orthostatic tachycardia syndrome (POTS) has gone up more than fourteen times compared to pre-pandemic (<a href="https://academic.oup.com/ehjqcco/advance-article-abstract/doi/10.1093/ehjqcco/qcae111/7945206" rel="nofollow noopener" translate="no" target="_blank">https://academic.oup.com/ehjqcco/advance-article-abstract/doi/10.1093/ehjqcco/qcae111/7945206</a>)</blockquote><a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/pandemic" class="mention hashtag" rel="nofollow noopener" target="_blank">#pandemic</a> <a href="https://zeroes.ca/tags/MaskUp" class="mention hashtag" rel="nofollow noopener" target="_blank">#MaskUp</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/cleanAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#cleanAir</a>

datum (n=1)<a href="https://normal.style/@jackdaw_ruiz" class="u-url mention" rel="nofollow noopener" target="_blank">@jackdaw_ruiz</a> COVID-19 is political. Assuming you've had that twice+, by the transitory property, when you can't get a boner, COVID-19 is political.Turns out it will cross the Blood Boner Barrier, too.<a href="https://zeroes.ca/@datum/113801129956767297" translate="no" rel="nofollow noopener" target="_blank">https://zeroes.ca/@datum/113801129956767297</a> <a href="https://climatejustice.social/@samara/114127585881644162" rel="nofollow noopener" translate="no" target="_blank">https://climatejustice.social/@samara/114127585881644162</a> <a href="https://mastodon.social/@augieray/112541711634337747" rel="nofollow noopener" translate="no" target="_blank">https://mastodon.social/@augieray/112541711634337747</a><a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> #🍆

datum (n=1)Most interesting detail: "we detected the virus passing from one sinus at the peak of infection to the other a few days later"Model animals: "cynomolgus macaques"They also evaluated "two convalescent animals [...] exposed to the SARS-CoV-2 Delta variant three months prior" and found "no major uptake by the nasal cavity" but "detection of the PET signal for SARS-CoV-2 spike antigen up to three months post initial infection in the lungs and brains""local accumulation [...] in areas of the brain [...] consistent with previous findings of neuroinflammation in humans infected with SARS-CoV-2 and in rhesus macaques up to six weeks after SARS-CoV-2 infection. The localized crossing of the blood-brain barrier (BBB) by the radiotracer in convalescent animals can be explained by thrombo-inflammation previously reported in patients with active long-COVID."<a href="https://www.nature.com/articles/s41467-025-58173-y" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s41467-025-58173-y</a>h/t <a href="https://zeroes.ca/@EricCarroll" class="u-url mention" rel="nofollow noopener" target="_blank">@EricCarroll</a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARSCoV2</a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener" target="_blank">#AirborneAware</a>

datum (n=1)➡️ Clean water - no cholera. ❌:bacteria: ➡️ Clean air - no covid. ❌:coronavirus: ➡️ Clean info - no disinformation. 📵🙊 <a href="https://zeroes.ca/tags/cleanAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#cleanAir</a> <a href="https://zeroes.ca/tags/cleanWater" class="mention hashtag" rel="nofollow noopener" target="_blank">#cleanWater</a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidCompetent</a> <a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/cholera" class="mention hashtag" rel="nofollow noopener" target="_blank">#cholera</a> <a href="https://zeroes.ca/tags/disinformation" class="mention hashtag" rel="nofollow noopener" target="_blank">#disinformation</a> <a href="https://zeroes.ca/tags/choleraInTheAgeOfCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#choleraInTheAgeOfCovid</a>

datum (n=1)long list of fediverse accounts of people and orgs that tell the truth about COVID and Long COVID

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